Adrenal Chill

NPN: #80089995

Clinical Research

KSM-66® ashwagandha has over 20 human clinical trials to support its efficacy in areas of memory and cognition, stress and anxiety, female sexual function, thyroid health, and weight management. Two studies are highlighted below.

Anxiety & Stress

A study involving 64 subjects with a history of chronic stress were evaluated for depression, anxiety, and stress after 8 weeks of supplementing with 300 mg capsules of KSM-66® twice daily. The results showed that the KSM66® group, when compared to placebo, had a significant reduction in stress, anxiety, and depression, and a decrease in serum cortisol levels of 27.9%! (1)


Percentage change from baseline in PSS (perceived stress scale), GHQ-28 questionnaire (Goldberg and Hillier 1979), DASS questionnaire (depression anxiety stress scale), and serum cortisol.

Female Sexual Function

The efficacy of KSM-66® ashwagandha was explored for sexual function in a group of women who had experienced sexual dysfunction and orgasm disorders. Fifty women were given either placebo or 300 mg capsules of KSM-66® capsules twice daily for 8 weeks. Results showed improvements in female sexual health, including arousal, lubrication, satisfaction, and orgasm.(2)


Sexual function was assessed using the Female Sexual Function Index (FSFI). The KSM-66® ashwagandha treated group showed higher FSFI scores compared to placebo.

1 Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of Ashwagandha root in reducing stress and anxiety in adults. Indian Journal of Psychological Medicine, 34(3), 255. doi: 10.4103/0253-7176.106022
2 Dongre, S., Langade, D., & Bhattacharyya, S. (2015). Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study. BioMed Research International, 2015, 1–9. doi: 10.1155/2015/284154.